Toll-like receptor 4 polymorphism associated with the response to whole-cell pertussis vaccination in children from the KOALA study.

نویسندگان

  • Sander Banus
  • Renske W B Bottema
  • Christine L E Siezen
  • Rob J Vandebriel
  • Johan Reimerink
  • Monique Mommers
  • Gerard H Koppelman
  • Barbara Hoebee
  • Carel Thijs
  • Dirkje S Postma
  • Tjeerd G Kimman
  • Foekje F Stelma
چکیده

We examined the association between haplotype tagging single-nucleotide polymorphisms in TLR4 and the pertussis toxin-specific immunoglobulin G response after whole-cell pertussis (wP) vaccination in 515 1-year-old children from the KOALA study. A lower titer was associated with the minor allele of rs2770150, supporting a role for Toll-like receptor 4 in the antibody response to wP vaccination.

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عنوان ژورنال:
  • Clinical and vaccine immunology : CVI

دوره 14 10  شماره 

صفحات  -

تاریخ انتشار 2007